Mikhail Blagosklonny, who serves as an oncologist, has been certified as a Medical Doctor and also as a Philosophy Doctor at the First Pavlov State Medical University in St. Petersburg. He is said to have been responsible for research articles that exceed 170. All of these articles are in relation to ageing as well as cancer. As may have guessed, this of course means that there are numerous articles with detailed research on ageing and the expected use of rapamycin in this field.
Mikhail worked at the Ordway Research Institute till the year 2009 .He later went on to become an oncology professor at the Roswell Park Cancer Institute, Buffalo in New York on the 15th of April. While there, Mikhail did numerous researches and even availed articles on tandfonline.com. At this point, he detailed a drug called Evirolimus and the effects it has on the elderly adult’s immunity. He also reviews when human beings shall end up with the help of his research. This particular research was named Rejuvenating Immunity: Anti-Ageing Drug, Eight Years Later. He is also the Editor – in – Chief at Onctotarget as well as Cell Cycle. Visit classroomvoices.org to read more about Mikhail.
By formulating a theory that involves the Targets of Rapamycin or TOR, he brings forth the hypothesis that ageing may be brought about by the hyperfunctionality of cells instead of molecular damage aggregation. With this in mind, Mikhail Blagosklonny has come up with the conclusion that it would be best to use Rapamycin to extend one’s life as well as prevent diseases. The headlines have been abuzz with the news that a Rapamycin analogy, Evirolimus can improve the immunity in elderly people. Doctor Nir Barzail believes that this has set a stage upon which could be great turning point for those in the research field.
The TOR Centric Model has three sources which are Longevity Genetics, Cellular Senescence, and Diseases. In the Genetics of Longevity, model organism research showed many genes increased life spans’ thanks to their inactivation. Some gerogenes were seen to encode a pathway from TOR but it is still unknown whether TOR pathway is central or if it is just one among many others. In Cellular Senescence, it was declared that activating the pathways promoting growth, then senescence will be achieved once the cycle of the cell is obstructed. By so doing, the mTOR then causes an instance of geroconversion. The mTOR network is made up of the gerogenes and gerosuppressors which makes its network quite exactly the same as the gerogenic pathways in model organisms. In diseases such as fibrosis, diabetic issues, and cancer, Parkinson and Alzheimers the mTOR was found in the human diseases study. Thanks to the studies carried out, it was seen that the introduction of mTOR is the cause of death in humans and not exactly enhanced age of someone. Read more on templeofthecave.com